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KLRC2
NKG2-C type II integral membrane protein is a protein that in humans is encoded by the KLRC2 gene. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. It plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Protein class
CD markers
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (dendritic cells, T-cells, Oligodendrocyte precursor cells)
Immune cell specificity
Group enriched (NK-cell, gdT-cell)
Cell line specificity
Cell line enhanced (GAMG, HEL, HeLa, HSkMC)
Interaction
Heterodimer with KLRD1; disulfide-linked. KLRD1-KLRC2 receptor complex interacts with TYROBP homodimer; this interaction is necessary for the expression on the cell surface (PubMed:20890284, PubMed:9655483). KLRD1-KLRC2 receptor complex can bind with low affinity to HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia (PubMed:18083576, PubMed:9486650).
Molecular function
Receptor
More Types Infomation
- Recombinant Mouse Anti-KLRC2 Antibody (CBL025) (NEUT-1658CQ)
-
- Species Reactivity: Human
- Type: IgG2
- Application: FC, Neut
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For Research Use Only. Not For Clinical Use.