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KMT2D
The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Low cell line specificity
Interaction
Component of the MLL2 complex (also named ASCOM complex), at least composed of catalytic subunit KMT2D/MLL2, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (PubMed:23508102, PubMed:17500065, PubMed:12482968, PubMed:16603732, PubMed:17021013, PubMed:17761849, PubMed:17851529). Forms a core complex with the evolutionary conserved subcomplex WRAD composed of WDR5, RBBP5, ASH2L/ASH2 and DPY30 subunits; WRAD differentially stimulates the methyltransferase activity (PubMed:25561738). Interacts with ESR1; interaction is direct (PubMed:16603732). Interacts (via WIN motif) with WDR5 (PubMed:22665483, PubMed:22266653).
Molecular function
Chromatin regulator, Methyltransferase, Transferase
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, IP, ELISA
- Recombinant Human Anti-KMT2D Soluble TCR (AE3) (KIH) (VS-0622-YF7326)
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Human Anti-KMT2D Recombinant Soluble TCR (clone M9) (scTCR-0619YC-S(P))
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Human Anti-KMT2D Recombinant Soluble TCR (clone K16) (scTCR-0618YC-S(P))
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Recombinant Human Anti-KMT2D Soluble TCR (BF11) (C-Cys) (VS-0622-YF4621)
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Recombinant Human Anti-KMT2D Soluble TCR (BD9) (C-Cys) (VS-0622-YF4620)
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Recombinant Human Anti-KMT2D Soluble TCR (BB10) (C-Cys) (VS-0622-YF4619)
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Recombinant Human Anti-KMT2D Soluble TCR (AE3) (C-Cys) (VS-0622-YF4618)
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Recombinant Human Anti-KMT2D Soluble TCR (BF11) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1913)
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Recombinant Human Anti-KMT2D Soluble TCR (BD9) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1912)
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Recombinant Human Anti-KMT2D Soluble TCR (BB10) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1911)
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Recombinant Human Anti-KMT2D Soluble TCR (AE3) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1910)
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Human Anti-KMT2D Recombinant Soluble TCR (clone JG4) (scTCR-0617YC-S(P))
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Human Anti-KMT2D Recombinant Soluble TCR (clone J15) (scTCR-0616YC-S(P))
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Human Anti-KMT2D Recombinant Soluble TCR (clone G9) (scTCR-0615YC-S(P))
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Human Anti-KMT2D Recombinant Soluble TCR (clone CC6) (scTCR-0614YC-S(P))
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Human Anti-KMT2D Recombinant Soluble TCR (clone BH5) (scTCR-0613YC-S(P))
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Human Anti-KMT2D Recombinant Soluble TCR (clone BF11) (scTCR-0612YC-S(P))
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Human Anti-KMT2D Recombinant Soluble TCR (clone BD9) (scTCR-0611YC-S(P))
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
- Human Anti-KMT2D Recombinant Soluble TCR (clone BB10) (scTCR-0610YC-S(P))
-
- Species Reactivity: Human
- Epitope: ALSPVIPLI
- MHC: HLA-A*02:01
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For Research Use Only. Not For Clinical Use.