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KPNB1
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene.
Protein class
Plasma proteins, Transporters
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Forms a complex with an importin alpha subunit (PubMed:8617227, PubMed:8692944). Forms a heterodimer with IPO7. Interacts with IPO7, SNUPN, RPL23A and XPO1 (PubMed:18187419, PubMed:20476751). The KPNB1/IPO7 heterodimer interacts with H1 histone. Interacts with H2A, H2B, H3 and H4 histones (By similarity). Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1 (PubMed:10367892). Interacts with SRY. Interacts with PRKCI/atypical protein kinase C iota. Interacts with KPNA7. Interacts with SNAI1 (via zinc fingers) and SNAI2 (via zinc fingers). Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with RAN (By similarity). Interacts with NUMA1 (via C-terminus); this interaction is inhibited by RanGTP (PubMed:11229403). Interacts with ZBED1/hDREF; required for nuclear import of ZBED1/hDREF (PubMed:17209048). (Microbial infection) Interacts with HIV-1 Rev and Tat. (Microbial infection) Interacts with HTLV-1 Rex. (Microbial infection) Interacts with human respiratory syncytial virus (HRSV) matrix protein; this interaction mediates nuclear import of the matrix protein early during infection. (Microbial infection) Part of a tetrameric complex composed of CRM1, importin alpha/beta dimer and the Venezuelan equine encephalitis virus (VEEV) capsid; this complex blocks the receptor-mediated transport through the nuclear pore.
More Types Infomation
- Recombinant Mouse Anti-KPNB1 Antibody (3E9) (NEUT-1672CQ)
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- Species Reactivity: Human, Mouse, Dog, Pig, Rat, Bovine
- Type: IgG2a
- Application: FC, ICC/IF, IHC, Inhib, IP, WB, ChIP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IP
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For Research Use Only. Not For Clinical Use.