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KREMEN2

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains.
Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Basal squamous epithelial cells, Spermatogonia, Basal keratinocytes, Intestinal goblet cells, Rod photoreceptor cells, Spermatocytes)

Immune cell specificity

Immune cell enhanced (naive B-cell, memory B-cell)

Cell line specificity

Cell line enhanced (HMC-1, MCF7, RPMI-8226, T-47d)

Interaction

Interacts with ERLEC1. Forms a ternary complex with DKK1 and LRP6.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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