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KRT19
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal enterocytes, Basal respiratory cells, Pancreatic endocrine cells, Extravillous trophoblasts, Urothelial cells, Club cells, Ductal cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (CAPAN-2, HBEC3-KT, MCF7, RT4, SK-BR-3, T-47d)
Interaction
Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein. (Microbial infection) Interacts with hepatitis C virus/HCV core protein.
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC, ICC, IHC
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, ICC, IHC-Fr, IHC-P, IP, WB
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, ICC, IHC-P, IHC-P, IP, WB
-
- Species Reactivity: E. coli, Human
- Type: Mouse IgG
- Application: WB, IHC, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC-P
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG2a
- Application: ELISA, WB, IHC
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Mouse Anti-KRT19 Recombinant Antibody (clone 11F5); Fab Fragment (NS-024CN-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: IHC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
-
- Species Reactivity: E. coli, Human
- Type: Mouse IgG
- Application: WB, IHC, IF, ELISA
-
- Species Reactivity: E. coli, Human
- Type: Mouse IgG
- Application: WB, IHC, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: IHC-P
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P
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For Research Use Only. Not For Clinical Use.