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LEF1
Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA) enhancer and confers maximal enhancer activity.
Protein class
Cancer-related genes, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Microglial cells, T-cells, Melanocytes)
Immune cell specificity
Immune cell enhanced (naive CD4 T-cell)
Cell line specificity
Group enriched (JURKAT, MOLT-4, REH)
Interaction
Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds ALYREF/THOC4, MDFI and MDFIC. Interacts with NLK.
Molecular function
Activator, DNA-binding
More Types Infomation
Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Related Diseases
Endometrial Cancer
Throid Cancer
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, ICC/IF, IHC-P, WB
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- Species Reactivity: Human
- Application: WB
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
- Mouse Anti-LEF1 Recombinant Antibody (VS3-WK1203) (VS3-WK1203)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB, IHC
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB, IF, IHC-P
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For Research Use Only. Not For Clinical Use.