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LIFR
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells
Protein class
Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Hepatic stellate cells, Astrocytes, Adipocytes, Endothelial cells, Oligodendrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, HHSteC, SCLC-21H)
Interaction
Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR.
Molecular function
Receptor
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IP
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- Species Reactivity: Mouse
- Type: IgG
- Application: ELISA
-
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, IHC-P
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- Species Reactivity: Human
- Application: FC, WB
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For Research Use Only. Not For Clinical Use.