LIME1

Intracellular

Cell type enriched (Plasma cells)

Group enriched (plasmacytoid DC, T-reg, memory CD4 T-cell, memory CD8 T-cell, naive CD8 T-cell, gdT-cell, naive CD4 T-cell, MAIT T-cell)

Cell line enhanced (Karpas-707, MOLT-4, RPMI-8226, U-266/70)

When phosphorylated in response to BCR activation, interacts with LYN, PIK3R1, PLCG2, and GRB2 (By similarity). When phosphorylated in response to TCR stimulation and/or CD4 co-stimulation, interacts with LCK, CSK, FYN, PTPN11/SHP2, GRB2, PIK3R1 and GRAP2.