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LNX1

This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene.
Protein class

Enzymes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Early spermatids, Excitatory neurons, Glandular and luminal cells, Adipocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (OE19)

Interaction

Interacts with the phosphotyrosine interaction domain of all isoforms of NUMB (By similarity). Interacts with MAGEB18 and MAGEF1. Interacts with the Coxsackievirus and adenovirus receptor CXADR. Interacts with endogenous retrovirus K protein Np9. IGSF5/JAM4 interacts with isoform 2 through the second PDZ domain, other isoforms may also interact with IGSF5/JAM4 (By similarity).

Molecular function

Transferase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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