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LRRC32
This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies.
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Extravillous trophoblasts, Hepatic stellate cells, Endothelial cells, Adipocytes, Smooth muscle cells, Sertoli cells)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Group enriched (ASC diff, ASC TERT1, HSkMC, HUVEC TERT2, U-2197)
Interaction
Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1 (PubMed:19651619, 22278742). Interacts with TGFB2 (PubMed:19651619). Interacts with TGFB3; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB3, leading to regulate activation of TGF-beta-3 (By similarity). Interacts with LAPTM4B; decreases TGFB1 production in regulatory T-cells (PubMed:26126825).
Molecular function
Growth factor binding
More Types Infomation
- Human Anti-LRRC32 Recombinant Antibody; Fab Fragment (HPAB-2840LY-F(E)) (HPAB-2840LY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
- Human Anti-LRRC32 Recombinant Antibody (HPAB-2841LY) (HPAB-2841LY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
- Human Anti-LRRC32 Recombinant Antibody (HPAB-2840LY) (HPAB-2840LY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
- Human Anti-LRRC32 Recombinant Antibody (HPAB-2839LY) (HPAB-2839LY)
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- Derivation: Chimeric (Rat/Human)
- Species Reactivity: Human
- Type: Chimeric (Rat/Human) IgG
- Application: ELISA
- Human Anti-LRRC32 Recombinant Antibody (HPAB-2838LY) (HPAB-2838LY)
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- Derivation: Chimeric (Rat/Human)
- Species Reactivity: Human
- Type: Chimeric (Rat/Human) IgG
- Application: ELISA
- Human Anti-LRRC32 Recombinant Antibody; scFv Fragment (HPAB-2841LY-S(P)) (HPAB-2841LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
- Human Anti-LRRC32 Recombinant Antibody; scFv Fragment (HPAB-2840LY-S(P)) (HPAB-2840LY-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
- Rat Anti-LRRC32 Recombinant Antibody; scFv Fragment (HPAB-2839LY-S(P)) (HPAB-2839LY-S(P))
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- Species Reactivity: Human
- Type: Rat scFv
- Application: ELISA
- Rat Anti-LRRC32 Recombinant Antibody; scFv Fragment (HPAB-2838LY-S(P)) (HPAB-2838LY-S(P))
-
- Species Reactivity: Human
- Type: Rat scFv
- Application: ELISA
- Human Anti-LRRC32 Recombinant Antibody; Fab Fragment (HPAB-2839LY-F(E)) (HPAB-2839LY-F(E))
-
- Derivation: Chimeric (Rat/Human)
- Species Reactivity: Human
- Type: Chimeric (Rat/Human) Fab
- Application: ELISA
- Human Anti-LRRC32 Recombinant Antibody; Fab Fragment (HPAB-2838LY-F(E)) (HPAB-2838LY-F(E))
-
- Derivation: Chimeric (Rat/Human)
- Species Reactivity: Human
- Type: Chimeric (Rat/Human) Fab
- Application: ELISA
- Mouse Anti-LRRC32 Recombinant Antibody; Fab Fragment (HPAB-2837LY-F(E)) (HPAB-2837LY-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-LRRC32 Recombinant Antibody; Fab Fragment (HPAB-2836LY-F(E)) (HPAB-2836LY-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-LRRC32 Recombinant Antibody; scFv Fragment (HPAB-2837LY-S(P)) (HPAB-2837LY-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Mouse Anti-LRRC32 Recombinant Antibody; scFv Fragment (HPAB-2836LY-S(P)) (HPAB-2836LY-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
-
- Species Reactivity: Human, Cynomolgus
- Type: Human scFv
- Application: ELISA, FC, WB
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- Species Reactivity: Human, Cynomolgus
- Type: Mouse scFv
- Application: ELISA, FC, WB
- Mouse Anti-LRRC32 Recombinant Antibody (HPAB-2837LY) (HPAB-2837LY)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
- Mouse Anti-LRRC32 Recombinant Antibody (HPAB-2836LY) (HPAB-2836LY)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
-
- Species Reactivity: Human, Cynomolgus
- Type: Human IgG1
- Application: ELISA, FC, WB
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For Research Use Only. Not For Clinical Use.