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MAP1LC3C
Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Fibroblasts, granulocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (SuSa)
Interaction
3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with TP53INP1 and TP53INP2 (PubMed:22470510). Interacts with CALCOCO2 (PubMed:23022382). Interacts with TECPR2 (PubMed:20562859). Interacts with TBC1D5 (PubMed:22354992). Found in a complex with UBQLN1 and UBQLN2 (PubMed:20529957). Interacts with UBQLN4 (via STI1 1 and 2 domains) (PubMed:23459205). Interacts with UBQLN1 in the presence of UBQLN4 (PubMed:23459205). Interacts with TRIM5 (PubMed:25127057). Interacts with ATG13 (PubMed:24290141). Interacts with MEFV and TRIM21 (PubMed:26347139). Interacts with WDR81; recruits MAP1LC3C to ubiquitinated protein aggregates in the aggrephagy process (PubMed:28404643). Interacts with MOAP1 (via LIR motif) (PubMed:33783314).
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.