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MAP2K5

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Group enriched (Late spermatids, Excitatory neurons, Inhibitory neurons, Oligodendrocytes, Oligodendrocyte precursor cells, Early spermatids, Astrocytes, Microglial cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity). (Microbial infection) Interacts with Yersinia YopJ.

Molecular function

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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