Enzymes, Metabolic proteins
Intracellular
Cell type enhanced (Glandular and luminal cells, Endometrial ciliated cells, Oligodendrocytes)
Group enriched (plasmacytoid DC, neutrophil, classical monocyte)
Cell line enhanced (A549, AN3-CA, HUVEC TERT2, MOLT-4)
Dimer. Interacts (via its D domain) with its substrates MAPK11, MAPK12, MAPK13 and MAPK14 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2 (By similarity). Interacts with DCTN1. Interacts with EIF2AK2/PKR. (Microbial infection) Interacts with Yersinia YopJ.
Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
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For Research Use Only. Not For Clinical Use.