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MAP2K6

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Glandular and luminal cells, Endometrial ciliated cells, Oligodendrocytes)

Immune cell specificity

Group enriched (plasmacytoid DC, neutrophil, classical monocyte)

Cell line specificity

Cell line enhanced (A549, AN3-CA, HUVEC TERT2, MOLT-4)

Interaction

Dimer. Interacts (via its D domain) with its substrates MAPK11, MAPK12, MAPK13 and MAPK14 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2 (By similarity). Interacts with DCTN1. Interacts with EIF2AK2/PKR. (Microbial infection) Interacts with Yersinia YopJ.

Molecular function

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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