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MAPK3

Engineered Antibody
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Protein class

Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, RAS pathway related proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Distal enterocytes, Early spermatids, Proximal enterocytes)

Immune cell specificity

Group enriched (eosinophil, neutrophil)

Cell line specificity

Low cell line specificity

Interaction

Binds both upstream activators and downstream substrates in multimolecular complexes. Found in a complex with at least BRAF, HRAS, MAP2K1/MEK1, MAPK3 and RGS14 (By similarity). Interacts with ADAM15, ARRB2, CANX, DAPK1 (via death domain), HSF4, IER3, MAP2K1/MEK1, MORG1, NISCH, and SGK1. Interacts with PEA15 and MKNK2 (By similarity). MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (By similarity). Interacts with TPR. Interacts with CDKN2AIP. Interacts with HSF1 (via D domain and preferentially with hyperphosphorylated form); this interaction occurs upon heat shock (PubMed:10747973). Interacts with CAVIN4 (By similarity). Interacts with GIT1; this interaction is necessary for MAPK3 localization to focal adhesions (By similarity). Interacts with ZNF263 (PubMed:32051553). (Microbial infection) Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity.

Molecular function

Kinase, Serine/threonine-protein kinase, Transferase

More Types Infomation
Related Signaling Pathways
FcεR1 Signaling Pathway FcεR1 Signaling Pathway
TCR Signaling Pathway TCR Signaling Pathway
Related Diseases
Maturity Onset Diabetes of the Young Maturity Onset Diabetes of the Young

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