Enzymes, Metabolic proteins
Intracellular, Membrane (different isoforms)
Low cell type specificity
Low immune cell specificity
Low cell line specificity
Interacts with ERK3/MAPK6 and ERK4/MAPK4 (via FRIEDE motif); the interaction is direct (By similarity). Interacts with YWHAE; the interaction prevents phosphorylation of HSP27/HSPB1 leading to disrupt F-actin polymerization. Interacts with SQSTM1.
Kinase, Serine/threonine-protein kinase, Transferase
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For Research Use Only. Not For Clinical Use.