Intracellular
Cell type enhanced (Adipocytes, Cone photoreceptor cells, Microglial cells, Oligodendrocytes, Bipolar cells, Endothelial cells)
Not detected in immune cells
Cell line enhanced (OE19, SCLC-21H, SH-SY5Y, SK-BR-3, WM-115)
Interacts with GTP-bound RAC1 (By similarity). Interacts with CDC42 (PubMed:15157669). Interacts with RHOA. Interacts with CCPG1, which results in specific inhibition of its exchange activity toward RHOA, but does not affect its activity on CDC42 (By similarity).
Guanine-nucleotide releasing factor
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For Research Use Only. Not For Clinical Use.