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MCM5
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cytotrophoblasts, monocytes, Erythroid cells, Syncytiotrophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the MCM2-7 complex (PubMed:17296731, PubMed:16899510). The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (PubMed:17296731, PubMed:16899510). Interacts with ANKRD17 (PubMed:23711367). Interacts with MCMBP (PubMed:17296731). Component of the CMG helicase complex, composed of the MCM2-7 complex, the GINS complex and CDC45 (By similarity).
Molecular function
DNA-binding, Helicase, Hydrolase
More Types Infomation
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, ICC, IHC-P, IP, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
- Mouse Anti-MCM5 Recombinant Antibody; scFv Fragment (HPAB-0044-LS-S(P)) (HPAB-0044-LS-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Mouse Anti-MCM5 Recombinant Antibody; scFv Fragment (HPAB-0043-LS-S(P)) (HPAB-0043-LS-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Mouse Anti-MCM5 Recombinant Antibody; Fab Fragment (HPAB-0044-LS-F(E)) (HPAB-0044-LS-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-MCM5 Recombinant Antibody; Fab Fragment (HPAB-0043-LS-F(E)) (HPAB-0043-LS-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-MCM5 Recombinant Antibody (HPAB-0044-LS) (HPAB-0044-LS)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
- Mouse Anti-MCM5 Recombinant Antibody (HPAB-0043-LS) (HPAB-0043-LS)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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For Research Use Only. Not For Clinical Use.