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MDK
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Protein class
Cancer-related genes
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Paneth cells, Enteroendocrine cells, Proximal enterocytes, Granulosa cells)
Immune cell specificity
Immune cell enhanced (neutrophil, memory B-cell)
Cell line specificity
Cell line enhanced (NTERA-2, REH, SH-SY5Y)
Interaction
Homodimer. Interacts with ALK (PubMed:12122009). Interacts with LRP1; promotes neuronal survival (PubMed:10772929). Interacts with LRP2 (PubMed:10772929). Interacts with NCAM1 (PubMed:10772929). Interacts (via C-terminal) with PTPRZ1 (via chondroitin sulfate chains); this interaction is inhibited by PTN; this interaction promotes neuronal migration (PubMed:10212223). Interacts with NCL; this interaction promotes NCL clustering and lateral movements of this complex into lipid rafts leading to MDK internalization (PubMed:12147681). Interacts with LRP6 and LRP8: this interaction is calcium dependent (PubMed:12573468). Interacts with ITGA4 (PubMed:15466886). Interacts with ITGA6 (PubMed:15466886). Interacts with ITGB1 (PubMed:15466886). Interacts with ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Interacts with ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886). Interacts with NOTCH2; this interaction mediates a nuclear accumulation of NOTCH2 and therefore activation of NOTCH2 signaling leading to interaction between HES1 and STAT3 (PubMed:18469519). Interacts with GPC2 (via heparan sulfate chain); this interaction is inhibited by heparin followed by chondroitin sulfate E; this interaction induces GPC2 clustering through heparan sulfate chain; this interaction induces neuronal cell adhesion and neurite outgrowth (PubMed:12084985). Interacts with SDC3; this interaction induces SDC3 clustering; this interaction induces neuronal cell adhesion and neurite outgrowth (PubMed:12084985). Interacts with SDC1 (By similarity). Interacts with CSPG5; this interaction promotes elongation of oligodendroglial precursor-like cells (By similarity).
Molecular function
Developmental protein, Growth factor, Heparin-binding, Mitogen
More Types Infomation
- PE-A*02:01/Human MDK (AQCQETIRV) MHC Tetramer (MHC-CN1029)
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- Class: Class I
- Antigen: MDK
- Antigen Species: Human
- Peptide: AQCQETIRV
- Conjugate: PE
- APC-A*02:01/Human MDK (AQCQETIRV) MHC Tetramer (MHC-CN1030)
-
- Class: Class I
- Antigen: MDK
- Antigen Species: Human
- Peptide: AQCQETIRV
- Conjugate: APC
- FITC-A*02:01/Human MDK (AQCQETIRV) MHC Tetramer (MHC-CN1031)
-
- Class: Class I
- Antigen: MDK
- Antigen Species: Human
- Peptide: AQCQETIRV
- Conjugate: FITC
- A*02:01/Human MDK (AQCQETIRV) MHC Tetramer (MHC-CN1032)
-
- Class: Class I
- Antigen: MDK
- Antigen Species: Human
- Peptide: AQCQETIRV
- Conjugate: Unconjugated
- PE-A*24:02/Human MDK (RYNAQCQETI) MHC Tetramer (MHC-CN1033)
-
- Class: Class I
- Antigen: MDK
- Antigen Species: Human
- Peptide: RYNAQCQETI
- Conjugate: PE
- APC-A*24:02/Human MDK (RYNAQCQETI) MHC Tetramer (MHC-CN1034)
-
- Class: Class I
- Antigen: MDK
- Antigen Species: Human
- Peptide: RYNAQCQETI
- Conjugate: APC
- FITC-A*24:02/Human MDK (RYNAQCQETI) MHC Tetramer (MHC-CN1035)
-
- Class: Class I
- Antigen: MDK
- Antigen Species: Human
- Peptide: RYNAQCQETI
- Conjugate: FITC
- A*24:02/Human MDK (RYNAQCQETI) MHC Tetramer (MHC-CN1036)
-
- Class: Class I
- Antigen: MDK
- Antigen Species: Human
- Peptide: RYNAQCQETI
- Conjugate: Unconjugated
- A*24:02/Human Midkine (RYNAQCQETI) MHC Pentamer (MHC-YF562)
-
- Class: Class I
- Antigen: Midkine
- Antigen Species: Human
- Peptide: RYNAQCQETI
- Conjugate: Unlabeled, Biotin, R-PE, APC
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC/IF, IHC-P, IP, WB
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, IP
- Human Anti-MDK Antibody, mRNA (TAB-519CL-mRNA)
-
- Species Reactivity: Human
- Human Anti-MDK Recombinant Antibody; scFv Fragment (TAB-0812CL-S(P)) (TAB-0812CL-S(P))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
- Mouse Anti-MDK Recombinant Antibody; scFv Fragment (TAB-0813CL-S(P)) (TAB-0813CL-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Human Anti-MDK Recombinant Antibody (clone EV3032); scFv Fragment (HPAB-AP735-YC-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Neut
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IHC
- Human Anti-MDK Recombinant Antibody (clone EV3032); Fab Fragment (HPAB-AP735-YC-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Neut
- Anti-Human MDK Recombinant Antibody (TAB-519CL)
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
- Human Anti-MDK Recombinant Antibody (TAB-0812CL) (TAB-0812CL)
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA
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For Research Use Only. Not For Clinical Use.