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MFNG

This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009]
Protein class

Enzymes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (NK-cells, dendritic cells, Hepatic stellate cells, Adipocytes, T-cells, Kupffer cells, monocytes, Endothelial cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (Daudi, HEL, HL-60, HMC-1, HUVEC TERT2, TIME, U-698, U-937)

Molecular function

Developmental protein, Glycosyltransferase, Transferase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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