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MGLL

This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Adipocytes, Pancreatic endocrine cells, Distal enterocytes)

Immune cell specificity

Immune cell enhanced (plasmacytoid DC, intermediate monocyte)

Cell line specificity

Cell line enhanced (BJ, BJ hTERT+, LHCN-M2, RPTEC TERT1)

Interaction

Homodimer.

Molecular function

Hydrolase, Serine esterase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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