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MKLN1
Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060).
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Astrocytes, Oligodendrocyte precursor cells, Excitatory neurons, Oligodendrocytes, Inhibitory neurons)
Immune cell specificity
Immune cell enriched (neutrophil)
Cell line specificity
Low cell line specificity
Interaction
Homodimer; may form higher oligomers (By similarity). Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5 (PubMed:17467196, PubMed:29911972). Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (PubMed:29911972). Interacts with RANBP9 (PubMed:18710924). Part of a complex consisting of RANBP9, MKLN1 and GID8 (PubMed:12559565). Interacts with GABRA1. Interacts with the C-terminal tail of PTGER3 (By similarity).
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, IP, FC
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For Research Use Only. Not For Clinical Use.