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MLYCD
The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cone photoreceptor cells, Cardiomyocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Homotetramer. Dimer of dimers. The two subunits within a dimer display conformational differences suggesting that at any given moment, only one of the two subunits is competent for malonyl-CoA binding and catalytic activity. Under oxidizing conditions, can form disulfide-linked homotetramers (in vitro). Associates with the peroxisomal targeting signal receptor PEX5.
Molecular function
Decarboxylase, Lyase
More Types Infomation
- Human Anti-MLYCD Antibody (clone M28), mRNA (FAMAB-0220YC-mRNA)
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- Species Reactivity: Rat
- Human Anti-MLYCD Antibody (clone M23), mRNA (FAMAB-0219YC-mRNA)
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- Species Reactivity: Rat
- Human Anti-MLYCD Antibody (clone M8), mRNA (FAMAB-0218YC-mRNA)
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- Species Reactivity: Rat
- Recombinant Anti-Human MLYCD Antibody scFv Fragment (MOB-2709z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, RIA, Biosensors, FuncS
- Recombinant Anti-Human MLYCD Antibody Fab Fragment (MOB-2709z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, FuncS
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, ICC/IF, IHC
- Human Anti-MLYCD Antibody (clone M4), mRNA (FAMAB-0217YC-mRNA)
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- Species Reactivity: Rat
- Human Anti-MLYCD Recombinant Antibody (clone M28) (FAMAB-0220YC)
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- Derivation: Phage display library
- Species Reactivity: Rat
- Type: Human IgG, κ
- Application: WB
- Human Anti-MLYCD Recombinant Antibody (clone M23) (FAMAB-0219YC)
-
- Derivation: Phage display library
- Species Reactivity: Rat
- Type: Human IgG, κ
- Application: WB
- Human Anti-MLYCD Recombinant Antibody (clone M8) (FAMAB-0218YC)
-
- Derivation: Phage display library
- Species Reactivity: Rat
- Type: Human IgG, κ
- Application: ELISA
- Human Anti-MLYCD Recombinant Antibody (clone M4) (FAMAB-0217YC)
-
- Derivation: Phage display library
- Species Reactivity: Rat
- Type: Human IgG, κ
- Application: ELISA
- Human Anti-MLYCD Recombinant Antibody (clone M28); Fab Fragment (FAMAB-0220-YC-F(E))
-
- Derivation: Phage display library
- Species Reactivity: Rat
- Type: Human Fab
- Application: WB
- Human Anti-MLYCD Recombinant Antibody (clone M23); Fab Fragment (FAMAB-0219-YC-F(E))
-
- Derivation: Phage display library
- Species Reactivity: Rat
- Type: Human Fab
- Application: WB
- Human Anti-MLYCD Recombinant Antibody (clone M8); Fab Fragment (FAMAB-0218-YC-F(E))
-
- Derivation: Phage display library
- Species Reactivity: Rat
- Type: Human Fab
- Application: ELISA
- Human Anti-MLYCD Recombinant Antibody (clone M4); Fab Fragment (FAMAB-0217-YC-F(E))
-
- Derivation: Phage display library
- Species Reactivity: Rat
- Type: Human Fab
- Application: ELISA
- Human Anti-MLYCD Recombinant Antibody (clone M28); scFv Fragment (FAMAB-0220-YC-S(P))
-
- Derivation: Phage display library
- Species Reactivity: Rat
- Type: Human scFv
- Application: WB
- Human Anti-MLYCD Recombinant Antibody (clone M23); scFv Fragment (FAMAB-0219-YC-S(P))
-
- Derivation: Phage display library
- Species Reactivity: Rat
- Type: Human scFv
- Application: WB
- Human Anti-MLYCD Recombinant Antibody (clone M8); scFv Fragment (FAMAB-0218-YC-S(P))
-
- Derivation: Phage display library
- Species Reactivity: Rat
- Type: Human scFv
- Application: ELISA
- Human Anti-MLYCD Recombinant Antibody (clone M4); scFv Fragment (FAMAB-0217-YC-S(P))
-
- Derivation: Phage display library
- Species Reactivity: Rat
- Type: Human scFv
- Application: ELISA
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