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MMP16

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.
Protein class

Cancer-related genes, Enzymes

Predicted location

Intracellular, Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Oligodendrocyte precursor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AN3-CA, HUVEC TERT2, SH-SY5Y, U-138 MG, WM-115)

Interaction

Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.

Molecular function

Hydrolase, Metalloprotease, Protease

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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