Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets
Intracellular, Secreted (different isoforms)
Cell type enhanced (Fibroblasts, Extravillous trophoblasts, Peritubular cells, Leydig cells, Endometrial stromal cells)
Not detected in immune cells
Cell line enhanced (ASC diff, ASC TERT1, hTERT-RPE1, U-87 MG)
Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.
Hydrolase, Metalloprotease, Protease
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For Research Use Only. Not For Clinical Use.