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MMS22L
The protein encoded by this gene forms a complex with tonsoku-like, DNA repair protein (TONSL), and this complex recognizes and repairs DNA double-strand breaks at sites of stalled or collapsed replication forks. The encoded protein also can bind with the histone-associated protein NFKBIL2 to help regulate the chromatin state at stalled replication forks. Finally, this gene appears to be overexpressed in most lung and esophageal cancers. Multiple transcript variants exist for this gene, but the full-length nature of only one has been determined to date.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Spermatocytes, Oligodendrocytes, Spermatogonia)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2.
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Human
- Type: IgG
- Application: WB, FC, IP
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For Research Use Only. Not For Clinical Use.