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MORC3
This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled-coil domain.
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer (PubMed:17332504, PubMed:30850548). The sumoylated form interacts with PML (via SUMO-interacting motif) (PubMed:20501696, PubMed:17332504). Interacts with TP53 (PubMed:17332504). (Microbial infection) Interacts with influenza A virus PA and PB1 polymerase subunits during infection (PubMed:26202233). Interacts (via CW domain) with influenza A protein NS1 (PubMed:31006586). (Microbial infection) Interacts with herpes simplex virus 1/HHV-1 protein ICP0; this interaction mediates MORC3 degradation, which leads to de-repression of a MORC3-regulated DNA element (MRE) adjacent to the IFNB1 locus.
Molecular function
RNA-binding
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IP
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For Research Use Only. Not For Clinical Use.