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MPRIP
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Low cell line specificity
Interaction
Binds F-actin through its N-terminus. Interacts with MYZAP (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.
Molecular function
Actin-binding
More Types Infomation
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
- Recombinant Anti-Human MPRIP Antibody scFv Fragment (MOB-2779z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IF, FuncS
- Recombinant Anti-Human MPRIP Antibody Fab Fragment (MOB-2779z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IP, FuncS
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For Research Use Only. Not For Clinical Use.