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MSH5

This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene.
Protein class

Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Cone photoreceptor cells, Spermatocytes, Plasma cells, Gastric mucus-secreting cells, Spermatogonia, Erythroid cells)

Immune cell specificity

Immune cell enhanced (basophil)

Cell line specificity

Cell line enhanced (Daudi, NB-4)

Interaction

Heterooligomer of MSH4 and MSH5. Interacts with HJURP.

Molecular function

DNA-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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