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MTUS1

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]
Protein class

Disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Oligodendrocytes, Adipocytes, Alveolar cells type 2)

Immune cell specificity

Immune cell enhanced (naive CD4 T-cell, naive CD8 T-cell)

Cell line specificity

Cell line enhanced (A549, AN3-CA, HUVEC TERT2, SK-MEL-30)

Interaction

Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity). Isoform 1 associates with microtubules.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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