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MYB

This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants.
Protein class

Cancer-related genes, Human disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Erythroid cells, Undifferentiated cells, Breast glandular cells, Respiratory ciliated cells, Intestinal goblet cells, Ionocytes, granulocytes)

Immune cell specificity

Group enriched (eosinophil, basophil, plasmacytoid DC)

Cell line specificity

Cell line enhanced (HL-60, MOLT-4, NB-4, REH, THP-1, U-937)

Interaction

Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1.

Molecular function

Activator, DNA-binding

More Types Infomation

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