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NAB2

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Protein class

Cancer-related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Syncytiotrophoblasts)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (SK-MEL-30)

Interaction

Homomultimers may associate with EGR1 bound to DNA.

Molecular function

Repressor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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