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NACC1
This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1.
Molecular function
Repressor
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, IHC-P
- Mouse Anti-NACC1 Recombinant Antibody (clone 6H2) (VS3-XY1132)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, ELISA
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For Research Use Only. Not For Clinical Use.