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NANOG

Engineered Antibody
The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene.
Protein class

Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Cone photoreceptor cells, Spermatocytes)

Immune cell specificity

Immune cell enhanced (plasmacytoid DC)

Cell line specificity

Cell line enriched (NTERA-2)

Interaction

Interacts with SMAD1 (By similarity). Interacts with SALL4 (By similarity). Interacts with ZNF281/ZFP281 (By similarity). Interacts with PCGF1 (PubMed:26687479). Interacts with ESRRB; reciprocally modulates their transcriptional activities (By similarity). Interacts with NSD2 (By similarity).

Molecular function

Activator, Developmental protein, DNA-binding, Repressor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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