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NDUFS4
This gene encodes an nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase). Complex I removes electrons from NADH and passes them to the electron acceptor ubiquinone. Mutations in this gene can cause mitochondrial complex I deficiencies such as Leigh syndrome. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Distal tubular cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme. Interacts with BCAP31 and TOMM40; the interaction mediates its translocation to the mitochondria; the interaction with BCAP31 is direct (PubMed:31206022).
More Types Infomation
- Recombinant Mouse Anti-Human NDUFS4 Antibody (MOB-1325MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ELISA, IF, IHC, IP
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- Species Reactivity: Human, Mouse, Rat
- Type: IgG
- Application: WB, IHC, FC, IP
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC, IP, FC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IHC, FC
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP, IHC, FC
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For Research Use Only. Not For Clinical Use.