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NEDD4L
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Alveolar cells type 1)
Immune cell specificity
Immune cell enriched (T-reg)
Cell line specificity
Cell line enhanced (SK-MEL-30)
Interaction
Interacts with UBE2E3 (By similarity). Interacts with NDFIP1; this interaction activates the E3 ubiquitin-protein ligase (PubMed:11748237, PubMed:26363003). Interacts with NDFIP2; this interaction activates the E3 ubiquitin-protein ligase (PubMed:26363003). Interacts (via WW domains) with SCNN1A (PubMed:11696533, PubMed:11244092, PubMed:14556380). Interacts (via WW domains) with SCNN1B (PubMed:11244092, PubMed:14556380). Interacts (via WW domains) with SCNN1G (PubMed:11244092, PubMed:14556380). Interacts (via WW domains) with SCN1A (By similarity). Interacts (via WW domains) with SCN2A (PubMed:15548568). Interacts (via WW domains) with SCN3A (PubMed:15548568). Interacts (via WW domains) with SCN5A (PubMed:15217910, PubMed:15548568). Interacts (via WW domains) with SCN8A (By similarity). Interacts (via WW domains) with SCN9A (By similarity). Interacts (via WW domains) with SCN10A (By similarity). Interacts (via WW domains) with CLCN5 (PubMed:15489223). Interacts with SMAD2 (PubMed:15496141). Interacts with SMAD3 (PubMed:15496141). Interacts with SMAD6 (PubMed:15496141). Interacts with SMAD7 (PubMed:15496141). The phosphorylated form interacts with 14-3-3 proteins (PubMed:15677482). Interacts with TNK2 (PubMed:19144635, PubMed:20086093). Interacts with WNK1 (PubMed:20525693). Interacts with SGK1 (PubMed:11696533, PubMed:20730100). Interacts (via C2 domain) with NPC2 (PubMed:19664597). Interacts with ARRDC4 (PubMed:23236378). Interacts with KCNQ1; promotes internalization of KCNQ1 (PubMed:22024150). Interacts (via domains WW1, 3 and 4) with USP36; the interaction inhibits ubiquitination of, at least, NTRK1, KCNQ2 and KCNQ3 by NEDD4L (PubMed:27445338). Interacts with PRRG4 (via cytoplasmic domain) (PubMed:23873930). Interacts with LDLRAD3; the interaction is direct (PubMed:26854353). Interacts with UBE2D2 (PubMed:20064473). (Microbial infection) Interacts with Epstein-Barr virus LMP2A.
Molecular function
Transferase
More Types Infomation
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP
- Recombinant Mouse Anti-Human NEDD4L Antibody (MOB-1330MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P, IP, WB
- Rabbit Anti-NEDD4L Recombinant Antibody (VS3-WK1108) (VS3-WK1108)
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.