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NEFM

Enables signaling receptor binding activity and toxic substance binding activity. Involved in several processes, including cellular response to estradiol stimulus; intermediate filament cytoskeleton organization; and nervous system development. Located in axon; neurofilament; and perikaryon. Used to study amyotrophic lateral sclerosis and congenital hypothyroidism. Biomarker of hypothyroidism; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease and human immunodeficiency virus infectious disease. Orthologous to human NEFM (neurofilament medium chain).
Protein class

Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Late spermatids, Early spermatids, Rod photoreceptor cells, Excitatory neurons, Spermatocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (HEK93)

Interaction

Forms heterodimers with NEFL; which can further hetero-oligomerize (in vitro) (By similarity). Forms heterodimers with INA (in vitro) (By similarity).

More Types Infomation
    • Species Reactivity: Bovine, Chicken, Horse, Human, Mouse, Pig, Rat
    • Type: Chicken antibody
    • Application: ICC, IF, IHC, WB

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