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NEK7
NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]
Protein class
Enzymes, Metabolic proteins, Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cardiomyocytes, Oligodendrocytes, Oligodendrocyte precursor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (BJ, fHDF/TERT166)
Interaction
Monomer (PubMed:21320329). Interacts with NEK9 (PubMed:19414596). Interacts with ANKS3; this interaction alters the subcellular distribution of NEK7 by preventing its nuclear translocation (PubMed:26188091). Interacts (via N-terminus) with NLRP3 (via LRR repeat domain); the interaction is required for the formation of the complex NLRP3:PYCARD, oligomerization of PYCARD and activation of CASP1 (By similarity).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC
-
- Species Reactivity: Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.