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NFYB
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Syncytiotrophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (SK-BR-3)
Interaction
Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.
Molecular function
Activator, DNA-binding
More Types Infomation
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- Species Reactivity: Human
- Application: Dot, WB
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For Research Use Only. Not For Clinical Use.