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NIN
This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Muller glia cells)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Low cell line specificity
Interaction
Homooligomer. Interacts with GSK3B/GSK3-beta via its C-terminal domain (PubMed:11004522). Interacts with C14ORF166, such interaction may prevent its phosphorylation by GSK3B (PubMed:15147888). Interacts with AUNIP (via N-terminus) (PubMed:20596670). Identified in a complex with AUNIP and AURKA (PubMed:20596670). Interacts with CCDC120 (PubMed:28422092). Interacts (via C-terminus) with CEP250 (By similarity). Interacts with CEP170 (By similarity). Interacts with the gamma-tubulin ring complex component TUBGCP3 (By similarity). Interacts with gamma-tubulin (By similarity). Isoform 6 does not interact with CEP170 or CEP250 (By similarity).
More Types Infomation
- Mouse Anti-NIN Recombinant Antibody (MOB-1892z) (MOB-1892z)
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- Species Reactivity: Mouse, Rat, Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
- Recombinant Anti-Human NIN Antibody scFv Fragment (MOB-1892z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, RIA, Biosensors, FuncS
- Recombinant Anti-Human NIN Antibody Fab Fragment (MOB-1892z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, FacS, FuncS
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For Research Use Only. Not For Clinical Use.