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NLRP12

May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK
Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (monocytes, Kupffer cells, Macrophages, granulocytes, Alveolar cells type 2, Alveolar cells type 1)

Immune cell specificity

Group enriched (basophil, neutrophil, eosinophil, classical monocyte)

Cell line specificity

Group enriched (HMC-1, THP-1, U-87 MG, U-937)

Interaction

Interacts (via pyrin domain) with ASC. Interacts (via pyrin domain) with FAF1 (via UBA domain) (PubMed:21978668). Interacts with MAP3K14; this interaction promotes proteasomal degradation of MAP3K14 (PubMed:17237370). Interacts with NOD2; this interaction promotes degradation of NOD2 through the ubiquitin-proteasome pathway (PubMed:30559449). Interacts with HSPA1A and HSPA8 (PubMed:17947705). Interacts with HSP90AA1 (PubMed:17947705, PubMed:30559449). Interacts with TRIM25; this interaction inhibits DDX58-mediated signaling pathway (PubMed:30902577).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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