Disease related genes, Human disease related genes
Intracellular
Cell type enhanced (monocytes, Kupffer cells, Macrophages, granulocytes, Alveolar cells type 2, Alveolar cells type 1)
Group enriched (basophil, neutrophil, eosinophil, classical monocyte)
Group enriched (HMC-1, THP-1, U-87 MG, U-937)
Interacts (via pyrin domain) with ASC. Interacts (via pyrin domain) with FAF1 (via UBA domain) (PubMed:21978668). Interacts with MAP3K14; this interaction promotes proteasomal degradation of MAP3K14 (PubMed:17237370). Interacts with NOD2; this interaction promotes degradation of NOD2 through the ubiquitin-proteasome pathway (PubMed:30559449). Interacts with HSPA1A and HSPA8 (PubMed:17947705). Interacts with HSP90AA1 (PubMed:17947705, PubMed:30559449). Interacts with TRIM25; this interaction inhibits DDX58-mediated signaling pathway (PubMed:30902577).
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For Research Use Only. Not For Clinical Use.