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NOS2
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17.
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Granulosa cells, Distal enterocytes, Extravillous trophoblasts, Proximal enterocytes, Undifferentiated cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (CACO-2, SCLC-21H)
Interaction
Homodimer (PubMed:10409685, PubMed:10074942). Interacts with SLC9A3R1 (PubMed:12080081). Interacts with GAPDH; induced by oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:25417112). Interacts with S100A8 and S100A9 to form the iNOS-S100A8/9 transnitrosylase complex (PubMed:25417112). Interacts with SPSB1, SPSB2 and SPSB4 (PubMed:21199876). Interacts with ELOC and CUL5 in the presence of SPSB1 or SPSB2 or SPSB4 (PubMed:21199876). Forms a complex with ASL, ASS1 and HSP90AA1; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway.
Molecular function
Calmodulin-binding, Oxidoreductase
More Types Infomation
Related Diseases
AGE-RAGE Signaling Pathway in Diabetic Complications
-
- Derivation: Phage display library screening
- Type: IgG
- Application: IHC-P, IHC-Fr
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, FC, IF, IHC, IP
- Rabbit Anti-NOS2 Polyclonal Antibody (MRO-1976-CN) (MRO-1976-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: IF, IHC, FC, WB
-
- Species Reactivity: Mouse
- Type: Mouse antibody
- Application: ICC/IF, WB
-
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB, FC
- Mouse Anti-NOS2 Recombinant Antibody (clone 4E5) (VS3-XY1171)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC
-
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC
-
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: ELISA, FC
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
-
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG1, κ
- Application: ELISA, FC
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG2a, κ
- Application: ELISA, FC
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: ELISA, FC
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