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NOS3

Engineered Antibody
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Protein class

Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Early spermatids, Endothelial cells, Late spermatids, Hepatic stellate cells, Adipocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (BEWO, HUVEC TERT2, K-562, TIME)

Interaction

Homodimer. Interacts with NOSIP and NOSTRIN (PubMed:11149895, PubMed:12446846). Interacts with HSP90AB1 (PubMed:23585225, PubMed:11149895, PubMed:12446846) (By similarity). Forms a complex with ASL, ASS1 and SLC7A1; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway (By similarity).

Molecular function

Calmodulin-binding, Oxidoreductase

More Types Infomation
Related Diseases
AGE-RAGE Signaling Pathway in Diabetic Complications AGE-RAGE Signaling Pathway in Diabetic Complications

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