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NOXA1
Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Gastric mucus-secreting cells, Proximal enterocytes, Distal enterocytes, Paneth cells)
Immune cell specificity
Immune cell enhanced (non-classical monocyte)
Cell line specificity
Cell line enhanced (CAPAN-2, EFO-21, MCF7, T-47d)
Interaction
NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interaction with YWHAZ prevents the interaction of NOXA1 with NOXO1 and RAC1 and its targeting to membranes, hence reducing its ability to activate NOX1. Interacts (via N-terminus) with SH3PXD2A and SH3PXD2B; the interaction is direct.
More Types Infomation
Related Signaling Pathways
p53 Signaling Pathway
Related Diseases
Amyotrophic Lateral Sclerosis
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IP
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For Research Use Only. Not For Clinical Use.