Disease related genes, Human disease related genes, Nuclear receptors, Transcription factors
Intracellular
Cell type enhanced (Hepatocytes, Cholangiocytes, Gastric mucus-secreting cells, Distal tubular cells, Proximal enterocytes, Exocrine glandular cells)
Not detected in immune cells
Cell line enriched (Hep G2)
Interacts (via N-terminus) with NEUROD1 (via N-terminus and C-terminus) (PubMed:14752053). Interacts with ID2 (PubMed:14752053). Interacts with RORG, NFIL3, NR1D1 and BHLHE41 (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (PubMed:14752053). Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1 (By similarity). Interacts with HNF4A; the resulting heterodimer is transcriptionnally inactive (PubMed:28128295). Interacts with DDX3X; this interaction disrupts the interaction between HNF4 and NR0B2/SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers (PubMed:28128295).
Receptor, Repressor
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For Research Use Only. Not For Clinical Use.