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NR1H4
This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Transcription factors, Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal enterocytes, Proximal tubular cells, Hepatocytes, Cholangiocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (Hep G2, HHSteC, RPTEC TERT1)
Interaction
Heterodimer (via C-terminus) with RXRA (via DBD); the heterodimerization enhances the binding affinity for LXXLL motifs from coactivators (PubMed:23462506, PubMed:30275017). Binds DNA predominantly as a heterodimer with RXRA. After activation by agonist binding interacts with coactivators. Interacts with NCOA1, NCOA2, PPARGC1A, CARM1, SETD7, PRMT1, GPS2, SMARCA4 and MED1 (PubMed:15202934, PubMed:14684751, PubMed:15187081, PubMed:15471871, PubMed:15911693, PubMed:17895379, PubMed:18755856, PubMed:19805516, PubMed:23462506, PubMed:12718892, PubMed:12718893, PubMed:18621523, PubMed:18391212, PubMed:19410460, PubMed:19586769). Interacts with EP300 and SMARCD1 (By similarity). Interacts with XRCC5 and XRCC6; decreasing NR1H4/FXR transactivation activity towards ABCB11/BSEP (PubMed:19833092). Interacts with PAGR1 AND NCOA6; indicative for an association with an MLL2/MLL3 complex (ASCOM) (PubMed:19556342).
Molecular function
Activator, DNA-binding, Receptor, Repressor
More Types Infomation
- Recombinant Mouse Anti-Human NR1H4 Antibody (MOB-2270MZ)
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.