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NTHL1
The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. Coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]
Protein class
Cancer-related genes, Disease related genes, Enzymes, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Hepatocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with YBX1 (By similarity) (PubMed:11287425). Interacts with ERCC5/XPG; the interaction stimulates NTHL1 activity and NTHL1 binding to its DNA substrate (PubMed:9927729).
Molecular function
Glycosidase, Hydrolase, Lyase
More Types Infomation
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- Species Reactivity: Human
- Application: WB, Dot
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB, IHC, IF, FC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF
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For Research Use Only. Not For Clinical Use.