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NTN1

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.
Protein class

Cancer-related genes, Disease related genes, Human disease related genes

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Oligodendrocyte precursor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BEWO, T-47d, U-2 OS, U-251 MG, WM-115)

Interaction

Binds to its receptors; DCC, UNC5A, UNC5B, UNC5C and probably UNC5D (PubMed:9950216). Binds to its receptor; DSCAM (PubMed:19196994). Interacts with APP (By similarity).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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