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NTRK3
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Excitatory neurons, Inhibitory neurons, Astrocytes, Microglial cells, Late spermatids, Early spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (U-138 MG)
Interaction
Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts with PTPRS (PubMed:25385546). Interacts with MAPK8IP3/JIP3 (By similarity).
Molecular function
Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
More Types Infomation
Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF, IHC
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, ICC/IF, WB
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- Species Reactivity: Human
- Type: IgG
- Application: ELISA
- Anti-Human NTRK3 Recombinant Antibody scFv Fragment (6.4.1) (TAB-182CQ-S(P))
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- Species Reactivity: Human, Rat
- Type: Human antibody
- Application: ELISA, WB
- Anti-Human NTRK3 Recombinant Antibody scFv Fragment (6.1.2) (TAB-185CQ-S(P))
-
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, WB
- Anti-Human NTRK3 Recombinant Antibody (6.4.1) (TAB-182CQ)
-
- Species Reactivity: Human, Rat
- Type: Human antibody
- Application: ELISA, WB
- Anti-Human NTRK3 Recombinant Antibody (6.1.2) (TAB-185CQ)
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- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, WB
- Human Anti-NTRK3 Antibody, mRNA (TAB-697CL-mRNA)
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- Species Reactivity: Human
- Anti-Human NTRK3 Therapeutical Antibody (TAB-697CL)
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- Species Reactivity: Human
- Type: Antibody
- Mouse Anti-NTRK3 Recombinant Antibody (VS3-WK1038) (VS3-WK1038)
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1, κ
- Application: WB
- Human Anti-NTRK3 Recombinant Antibody (clone A5); Fab Fragment (HPAB-0198-CN-F(E))
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- Derivation: Human
- Species Reactivity: Human, Rat
- Type: Human Fab
- Application: ELISA, ICC
- Anti-Human NTRK3 Recombinant Antibody (2248) (TAB-184CQ)
-
- Species Reactivity: Human
- Application: Agonist, ELISA
- Anti-Human NTRK3 Recombinant Antibody (2256) (TAB-183CQ)
-
- Species Reactivity: Human, Rat
- Application: ELISA, WB
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG1, κ
- Application: ELISA, IF, WB, FC
- Mouse Anti-NTRK3 Recombinant Antibody (clone 7H6) (VS3-XY1194)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC
- Mouse Anti-NTRK3 Recombinant Antibody (clone 4G5) (VS3-XY1193)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1, κ
- Application: WB
- Human Anti-NTRK3 Recombinant Antibody (clone A5) (HPAB-0198-CN)
-
- Derivation: Human
- Species Reactivity: Human, Rat
- Type: Human IgG2a, κ
- Application: ELISA, ICC
- Anti-Human NTRK3 Recombinant Antibody scFv Fragment (2248) (TAB-184CQ-S(P))
-
- Species Reactivity: Human
- Application: ELISA, WB
- Anti-Human NTRK3 Recombinant Antibody scFv Fragment (2256) (TAB-183CQ-S(P))
-
- Species Reactivity: Human, Rat
- Application: ELISA, WB
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