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NUMB
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Protein class
Cancer-related genes
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Low cell line specificity
Interaction
Interacts with SIAH1 (PubMed:11752454). Interacts with LNX (By similarity). Interacts with CDH1 (By similarity). Interacts with TFAP2A and TFAP2B (By similarity). Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis (PubMed:12775724). Interacts with AAK1 (PubMed:18657069). May interact with DUOXA1 (PubMed:14670962).
Molecular function
Developmental protein
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IHC
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For Research Use Only. Not For Clinical Use.