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OGDH
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Protein class
Citric acid cycle related proteins, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cardiomyocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2) and DLD (dihydrolipoamide dehydrogenase; E3). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A (PubMed:29211711).
Molecular function
Oxidoreductase
More Types Infomation
- PE-H2-Ld/Human OGDH (LSPFPFDL) MHC Tetramer (MHC-LC4484)
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- Class: Class I
- Antigen: OGDH
- Antigen Species: Human
- Peptide: LSPFPFDL
- Conjugate: PE
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, ICC, IF
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC, ICC/IF, IP, ELISA, WB
- Recombinant Mouse Anti-Ogdh Soluble TCR (m67) (C-Cys) (VS-0622-YF4769)
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H2-Ld
- Recombinant Mouse Anti-OGDH Soluble TCR (QB6/8) (KIH) (VS-0622-YF5779)
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-OGDH Soluble TCR (QB4) (KIH) (VS-0622-YF5778)
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-OGDH Soluble TCR (QB7) (ZIP-Fos/ZIP-Jun) (VS-0622-YF364)
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-OGDH Soluble TCR (QB4) (ZIP-Fos/ZIP-Jun) (VS-0622-YF362)
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-OGDH Soluble TCR (42F3) (ZIP-Fos/ZIP-Jun) (VS-0622-YF361)
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-OGDH Soluble TCR (clone QB4) (scTCR-363CQ-S(P))
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-OGDH Soluble TCR (clone 42F3) (scTCR-362CQ-S(P))
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-OGDH Soluble TCR (clone 2C(m6)) (scTCR-361CQ-S(P))
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-OGDH Soluble TCR (clone QB2) (scTCR-360CQ-S(P))
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-OGDH Soluble TCR (42F3) (KIH) (VS-0622-YF5777)
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-OGDH Soluble TCR (2C(m6)) (KIH) (VS-0622-YF5776)
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-OGDH Soluble TCR (QB2) (KIH) (VS-0622-YF5775)
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-Ogdh Soluble TCR (m67) (ZIP-Fos/ZIP-Jun) (VS-0622-YF2061)
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H2-Ld
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-OGDH Soluble TCR (QB2) (ZIP-Fos/ZIP-Jun) (VS-0622-YF359)
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- Species Reactivity: Mouse
- Epitope: QLSPFPFDL
- MHC: H-2Ld
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